Portal de Periódicos da CAPES

Artigo Produção Nacional Revisado por pares

BIBTEX RIS

INCREASED TYROSINE HYDROXYLASE IMMUNOREACTIVITY IN THE LOCUS COERULEUS OF CATS WITH INTERSTITIAL CYSTITIS

1998; Lippincott Williams & Wilkins; Volume: 159; Issue: 3 Linguagem: Inglês

10.1016/s0022-5347(01)63833-3

1527-3792

Archivaldo Reche, C. A. Tony Buffington,

Urological Disorders and Treatments

No AccessJournal of UrologyInvestigative Urology1 Mar 1998INCREASED TYROSINE HYDROXYLASE IMMUNOREACTIVITY IN THE LOCUS COERULEUS OF CATS WITH INTERSTITIAL CYSTITIS ARCHIVALDO RECHE and C.A. TONY BUFFINGTON ARCHIVALDO RECHEARCHIVALDO RECHE and C.A. TONY BUFFINGTONC.A. TONY BUFFINGTON View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)63833-3AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Environmental stressors seem to play a role in exacerbation of symptoms of interstitial cystitis (IC), both in cats and in human beings. These observations suggest a role for the sympathetic nervous system in the pathophysiology of IC. To begin to assess the underlying role in IC of the pontine nucleus locus coeruleus (LC), the most important source of norepinephrine in the central nervous system, we compared the intensity of tyrosine hydroxylase immunoreactivity (THIR) in sections of LC obtained from cats with IC and from healthy cats. Cats with IC were studied during quiescent periods in an attempt to avoid the risk of flare-induced activation of the LC. Materials and Methods: Six cats diagnosed with IC and six healthy cats were studied. Cats with IC were monitored to ensure that no behavioral or urinary signs attributable to IC had been observed for at least two weeks prior to the study. Cats were euthanized and perfused with 4% paraformaldehyde, after which brainstem tissues were collected. Coronal sections (10 micro m.) of LC were prepared and examined for THIR. Results: THIR in total LC, parabrachial nucleus and LC complex was significantly greater (p <0.05) in samples from cats with IC than from healthy cats. Conclusions: The increased THIR in the LC of cats with IC provides additional evidence for increased sympathetic nervous system activity in patients with IC, even during periods of absence of clinical signs. References 1 : Interstitial cystitis. In: Campbell's Urology, Update 14. Edited by . Philadelphia: W. B. Saunders1995: 1. Google Scholar 2 : Interstitial cystitis in cats. Vet. Clin. North Am. Sm. Anim. Pract.1996; 26: 317. Google Scholar 3 : Self-care regimens for patients with interstitial cystitis. Urol. Clin. North Am.1994; 21: 121. Crossref, Medline, Google Scholar 4 : Central noradrenergic neurones and stress. Pharmacol. Ther.1995; 68: 297. Google Scholar 5 : Afferent projections to the cat locus coeruleus as visualized by the horseradish peroxidase technique. Brain Res.1977; 119: 21. Google Scholar 6 : Locus coeruleus neurons and sympathetic nerves: activation by visceral afferents. Brain Res.1986; 375: 117. Google Scholar 7 : Stress, antidepressant drugs, and the locus coeruleus Brain Res. Bull.1994; 35: 545. Google Scholar 8 : Single-unit response of noradrenergic neurons in the locus coeruleus of freely moving cats. I. Acutely presented stressful and nonstressful stimuli. J. Neurosci.1987; 7: 2837. Google Scholar 9 : Catecholamines in individual hypothalamic nuclei of acutely and repeatedly stresses rats. Neuroendocrinology1977; 23: 257. Google Scholar 10 : Neurochemical studies of central noradrenergic responses to acute and chronic stress-implications for normal and abnormal behavior. In: Neurobiological and Clinical Consequences of Stress-From Normal Adaptation to Post-Traumatic Stress Disorder.. Edited by . Philadelphia: Lippincott-Raven1995: 45. chapt. 3. Google Scholar 11 : Tryosine hydroxylase activity in noradrenergic neurons of the locus coeruleus after reserpine administration: sequential increase in cell bodies and nerve terminals. J. Neurochem.1979; 32: 23. Google Scholar 12 : Locus coeruleus neuronal activity in behaving animals. In: The Pharmacology of Noradrenaline in the Central Nervous System. Edited by . New York: Oxford University Press1990: 248. chapt. 8. Google Scholar 13 : Locus coeruleus activation by physiological challenges. Brain Res. Bull.1994; 35: 557. Google Scholar 14 : Clinical assessment of catecholaminergic function. In: Stress, Catecholamines and Cardiovascular Disease. New York: Oxford University Press1995: 234. chapt. 5. Google Scholar 15 : Plasma neurotransmitters and cortisol in chronic illness: role of stress. J. Med.1994; 25: 181. Google Scholar 16 : Clinical evaluation of cats with non-obstructive lower urinary tract disease: 109 cases, 1993-1995. J. Am. Vet. Med. Assoc.1997; 210: 46. Google Scholar 17 : The brain stem of the cat. A Cytoarchitectonic Atlas with Stereotaxic Coordinates. Madison: The University of Wisconsin Press1968. Google Scholar 18 : Les neurones contenant des catecholamines du tegmentum pontique et leurs voies de projection chez le chat. Brain Res.1973; 57: 119. Google Scholar 19 : Intermittent alkaline urine in a cat fed an acidifying diet. J. Am. Vet. Med. Assoc.1996; 209: 103. Google Scholar 20 : Quantitative immunocytochemistry of tyrosine hydroxylase in rat brain. I. Development of a computer assisted method using the peroxidase-antiperoxidase technique. Brain Res.1982; 246: 225. Google Scholar 21 : Sympatholytic effect of tricyclic antidepressants: site and mechanism of action in anesthetized rats. Am. J. Physiol.1995; 268: R1429. Medline, Google Scholar 22 : Differential action of amitriptyline on neurons in the trigeminal nucleus. Neurology1991; 41: 1932. Google Scholar 23 : Abnormal pedal thermoregulation in interstitial cystitis. Neurourol. Urodyn.1993; 12: 139. Crossref, Medline, Google Scholar 24 : Interstitial cystitis: increased sympathetic innervation and related neuropeptide synthesis. J. Urol.1992; 147: 587. Link, Google Scholar 25 : Sympathetic blockade in the management of interstitial cystitis. J. Urol.1992; 147: 223A. Google Scholar 26 : Monoamines in the parabrachial nucleus of the cardiomyopathic hamster. Brain Res.1995; 680: 117. Google Scholar From the Department of Medical Clinics, Faculdade de Medicina Veterinaria e Zootecnia, Universidade de Sao Paulo, Brazil and the Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Ohio State University, Columbus, Ohio.© 1998 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited bySadler K and Kolber B (2016) Urine Trouble: Alterations in Brain Function Associated with Bladder PainJournal of Urology, VOL. 196, NO. 1, (24-32), Online publication date: 1-Jul-2016.Stav K, Lang E, Fanus Z and Leibovici D (2012) Autonomic Response During Bladder Hydrodistention in Patients with Bladder Pain SyndromeJournal of Urology, VOL. 188, NO. 1, (117-121), Online publication date: 1-Jul-2012.LUTGENDORF S, LATINI J, ROTHROCK N, ZIMMERMAN M and KREDER K (2018) AUTONOMIC RESPONSE TO STRESS IN INTERSTITIAL CYSTITISJournal of Urology, VOL. 172, NO. 1, (227-231), Online publication date: 1-Jul-2004.Buffington C, Teng B and Somogyi G (2018) Norepinephrine Content And Adrenoceptor Function In The Bladder Of Cats With Feline Interstitial CystitisJournal of Urology, VOL. 167, NO. 4, (1876-1880), Online publication date: 1-Apr-2002.WESTROPP J and BUFFINGTON C (2018) IN VIVO MODELS OF INTERSTITIAL CYSTITISJournal of Urology, VOL. 167, NO. 2 Part 1, (694-702), Online publication date: 1-Feb-2002.PROPERT K, SCHAEFFER A, BRENSINGER C, KUSEK J, NYBERG L and LANDIS J (2018) A PROSPECTIVE STUDY OF INTERSTITIAL CYSTITIS: RESULTS OF LONGITUDINAL FOLLOWUP OF THE INTERSTITIAL CYSTITIS DATA BASE COHORTJournal of Urology, VOL. 163, NO. 5, (1434-1439), Online publication date: 1-May-2000.PEEKER R, ALDENBORG F, DAHLSTRÖM A, JOHANSSON S, LI J and FALL M (2018) INCREASED TYROSINE HYDROXYLASE IMMUNOREACTIVITY IN BLADDER TISSUE FROM PATIENTS WITH CLASSIC AND NONULCER INTERSTITIAL CYSTITISJournal of Urology, VOL. 163, NO. 4, (1112-1115), Online publication date: 1-Apr-2000. Volume 159Issue 3March 1998Page: 1045-1048 Advertisement Copyright & Permissions© 1998 by American Urological Association, Inc.MetricsAuthor Information ARCHIVALDO RECHE More articles by this author C.A. TONY BUFFINGTON More articles by this author Expand All Advertisement PDF downloadLoading ...