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The use of amorphous solid dispersions: A formulation strategy to overcome poor solubility and dissolution rate

2011; Elsevier BV; Volume: 9; Issue: 2 Linguagem: Inglês

10.1016/j.ddtec.2011.10.002

1740-6749

Guy Van den Mooter,

Protein purification and stability

The use of amorphous solid dispersions is an interesting strategy to increase the bioavailability of poorly soluble drugs by improving their rate and extent of dissolution. Lack of understanding of the physical chemistry and their in vivo behavior still hamper full breakthrough in pharmaceutical industry. This paper aims to review aspects like the amorphous state, manufacturing, characterization and biopharmaceutical testing to better understand the strength and weakness of this formulation strategy.