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Serum ionized magnesium in diabetic older persons

2013; Elsevier BV; Volume: 63; Issue: 4 Linguagem: Inglês

10.1016/j.metabol.2013.12.003

1532-8600

Mario Barbagallo, Giovanna Di Bella, Virna Brucato, Daniela D’Angelo, Provvidenza Damiani, Alfredo Monteverde, Mario Belvedere, Ligia J. Domínguez,

Parathyroid Disorders and Treatments

Objective.Several alterations of magnesium metabolism have been associated with type 2 diabetes pathophysiology, a condition particularly frequent in older persons.We aimed to evaluate serum total (Mg-tot) and serum ionized magnesium (Mg-ion) in older persons with type 2 diabetes in order to explore clinically applicable methods for the detection of magnesium deficit.Material/Methods.Mg-tot and Mg-ion were measured in 105 fasting subjects with type 2 diabetes (mean age: 71.1 ± 0.8 years; M/F: 45/60) and in 100 age-matched non-diabetic control persons (mean age: 72.2 ± 0.8 years; M/F: 42/58).Results.Mg-ion concentrations were significantly lower in diabetic persons compared with controls (0.49 ± 0.05 mmol/L vs. 0.55 ± 0.05 mmol/L; p < 0.001).Mg-tot was also slightly but significantly lower in diabetic patients (0.82 ± 0.007 mmol/L vs. 0.84 ± 0.006 mmol/L; p < 0.05).There was an almost complete overlap in the values of Mg-tot in older diabetic patients and controls; conversely, 44.8% of diabetic patients had Mg-ion values below 0.47 mmol/L, while none of the controls did.After adjustment for age, sex, BMI, and triglycerides, Mg-tot was significantly associated with FBG in all the participants (p < 0.05) and Mg-ion was significantly associated with FBG in all the participants (p < 0.01) and with HbA1c in diabetic participants (p < 0.001).Conclusions.Alterations of magnesium serum concentrations are common in type 2 diabetic older adults; Mg-ion evaluation may help to identify subclinical magnesium depletion (i.e. in patients with normal Mg-tot); the close independent associations of Mg-tot and Mg-ion with FBG and with HbA1c reinforce the possible link between magnesium homeostasis and altered glucose metabolism.