Zeolitic imidazolate framework-8 as efficient pH-sensitive drug delivery vehicle
2012; Royal Society of Chemistry; Volume: 41; Issue: 23 Linguagem: Inglês
10.1039/c2dt30357d
ISSN1477-9234
AutoresChunyi Sun, Chao Qin, Xinlong Wang, Guang‐Sheng Yang, Kui‐Zhan Shao, Ya‐Qian Lan, Zhong‐Min Su, Peng Huang, Chungang Wang, En‐Bo Wang,
Tópico(s)Covalent Organic Framework Applications
ResumoZeolitic Imidazolate Framework-8 (ZIF-8), for the first time for ZIFs, exhibits a remarkable capacity for the anticancer drug 5-fluorouracil (5-FU), around 660 mg of 5-FU/g of ZIF-8, and presents a pH-triggered controlled drug release property. These prove ZIF-8 to be a valuable candidate for delivery of anticancer agents and reveal its potential applications in the treatment of cancer.
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