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Amino Acid Analysis after Degradation of Angiotensin II by Rat Kidney Lysosomes

1969; Japanese Circulation Society; Volume: 33; Issue: 2 Linguagem: Inglês

10.1253/jcj.33.87

1347-4839

Noboru Saito, Keiko Sanada, Masato Matsunaga, Jun Ichi Kira, Sakae Mukaino, Kōichi Ogino, Masao Takayasu,

Aldose Reductase and Taurine

Phenylalanine and proline in this order were liberated more predominantly at pH 5.0 during short incubation periods by rat kidney lysosomal fraction, followed by slight releasing of histidine, valine or isoleucine. It was observed that the amino acids released were limited to four successive ones from COOH-terminal during short incubation up to 15 minutes in degradation of angiotensin II. Therefore, the possibility of endopeptidasic (chymotrypsin-like) and exopeptidasic actions was suggested in the present investigation.