Vapor Toxicity of UDMH in Rats and Dogs From Short Exposures
1963; Taylor & Francis; Volume: 24; Issue: 2 Linguagem: Inglês
10.1080/00028896309342941
ISSN2163-369X
AutoresMaurice H. Weeks, George C. Maxey, Mary E. Sicks, Earle A. Greene,
Tópico(s)Effects and risks of endocrine disrupting chemicals
ResumoAbstract A study was made of the inhalation toxicity of UDMH in animals from single short exposures. Five- to sixty-minute exposure of dogs and rats to high concentrations of UDMH produce toxic signs similar to those resulting from longer inhalation exposures. No clinical abnormalities resulted from these single short-term exposures. Dogs exposed to 50, 200, and 600 ppm of UDMH for single or multiple periods of 60-, 15-, and 5-minute duration, respectively, showed no adverse physiological effects. These levels of UDMH can serve as a basis from which short-term exposure standards may be estimated for man. Dogs retained about 80 per cent of the inhaled UDMH.
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