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Short-term kinetics of torque teno virus viraemia after induction immunosuppression confirm T lymphocytes as the main replication-competent cells

2014; Microbiology Society; Volume: 96; Issue: 1 Linguagem: Inglês

10.1099/vir.0.070094-0

1465-2099

Daniele Focosi, Lisa Macera, Ugo Boggi, Luca Ceccherini‐Nelli, Fabrizio Maggi,

Virus-based gene therapy research

Torque teno virus (TTV) is increasingly considered a universal marker of global immune function. The virus is supposed to replicate in lymphocytes, but poor information is available about fluctuations of viraemia after administration of anti-lymphocyte agents. We studied TTV kinetics in a cohort of 70 kidney±pancreas recipients receiving one of two different anti-T-cell induction immunosuppressants. During the first 30 days after anti-T-cell antibody administration, we report kinetics of TTV viraemia compatible with replication in T lymphocytes, and highly dependent on the potency of the anti-T-cell drug administered.