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Immunopharmacological study of CCA(Lobenzarit disodium), an anti-arthritis agent — I. Abrogation of IL 1 secretion by LPS-stimulated human monocytes and induction of γ-interferon production with CCA

1986; Elsevier BV; Volume: 8; Issue: 3 Linguagem: Inglês

10.1016/0192-0561(86)90114-1

1879-3495

Masao Fujimoto, Isamu Sugawara, Makoto Kimoto, Shigeaki Ishizaka, Tadasu Tsujii,

Immune Cell Function and Interaction

In vitro effects of CCA, an anti-arthritis agent, were studied upon autologues mixed lymphocyte reaction (AMLR), lymphocyte mitogenesis, IL 1 and IL 2 production, immunoglobulin production and γ-interferon (IFN) production. CCA at 50 μg/ml, which was not toxic to cells, blocked AMLR, IL 1 production and immunoglobulin production (IgM and IgG) significantly, while CCA at the same dose did not affect IL 2 production and lymphocyte mitogenic responses to Staphylococcus aureus Cowan I(SAC) and pokeweed mitogen(PWM). CCA at both 20 ng/ml and 20 μg/ml induced human γ/IFN. Addition of IL 1 and/or IL 2 reversed inhibitory effect of CCA on AMLR. These data suggest that CCA exerts its actions by mainly affecting T cells and monocytes and can be used as an immunomodulator.