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NADPH Generating Enzymes in Leydig Cells from Diabetic Rats

1979; Thieme Medical Publishers (Germany); Volume: 11; Issue: 02 Linguagem: Inglês

10.1055/s-0028-1092701

1439-4286

Juan Carlos Calvo, Luiz Biella de Souza Valle, JOS Eacute LINO S. BARAÑAO, Marta Tesone, Eduardo H. Charreau,

Diet, Metabolism, and Disease

Impaired testosterone biosynthesis in Leydig cells from streptozotocin treated rats is correlated with the reduced activity of glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase and isocitrate dehydrogenase. The results shown demonstrate that in the diabetic state the activity of these enzymes is reduced by almost 50 to 59% from normal levels. Insulin treatment restored their activities to normal levels.