LH-FSH/RH: an equally potent stimulus for the release of HLH and HFSH
1975; Elsevier BV; Volume: 4; Issue: 6 Linguagem: Inglês
10.1016/0028-2243(75)90048-9
ISSN1872-7654
AutoresPh. Koninckx, Pieter De Moor, Ivo Brosens,
Tópico(s)Reproductive Biology and Fertility
ResumoBlood was sampled continuously both before and after a single i.v.injection of 50,~g synthetic LH-FSH/RH in 5 normal women during the luteal phase of the cycle and in 5 women with hypoestrogenic secondary amenorrhea.LH, but not FSH concentrations were significantly higher at the beginning than at the end of the control sampling period.This phenomenon can be ascribed to the stress occasioned by initiating the blood sampling procedure.LH levels were lower, and FSH levels were higher in the group of women with amenorrhea than in the control group.These differences, however, were significant only after stimulation with LH-FSH/RH.Production rates were calculated using a single compartment model.In both groups studied maximal production rates occurred after 10 min for LH and after 20 min for FSH.Although the LH concentration increased relatively much more than the FSH concentration, the production rates of both hormones increased in the same proportion.This seems to indicate that LH-FSH/RH is an equally potent stimulus for the release of both gonadotropins.LH-FSH/RH; LH; FSH: gonadotropin production rates
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