Rodent models of arthritis: relevance for human disease
1998; Oxford University Press; Volume: 114; Issue: 3 Linguagem: Inglês
10.1046/j.1365-2249.1998.00785.x
ISSN1365-2249
Autores Tópico(s)Pharmacological Effects of Natural Compounds
ResumoRheumatoid arthritis (RA) is a chronic disabling disease affecting around 1% of the population. Although much has been learnt in recent years about the mediators that drive the pathology in RA, there is still a lack of knowledge of the underlying causes of the disease. It is for this reason, together with the need for more effective and less toxic remedies, that animal models of arthritis are being studied. Rodent models are used in a wide variety of different studies, including the testing of novel therapies, the identification of proinflammatory mediators, the analysis of genetic susceptibility factors and in the search for markers of disease progression.
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