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Long-term prognosis of patients with clinical unstable angina pectoris without elevation of creatine kinase but with elevation of cardiac troponin i levels

2002; Elsevier BV; Volume: 90; Issue: 8 Linguagem: Inglês

10.1016/s0002-9149(02)02712-1

1879-1913

Ronnier J. Aviles, R. Scott Wright, Jennifer M. Aviles, Furman S. McDonald, Karla V. Ballman, Amy Harker-Murray, Christopher G. Scott, Michael S. Lauer, Stephen L. Kopecky, Allan S. Jaffe,

Coronary Interventions and Diagnostics

A recent consensus statement advocated that patients with elevated cardiac troponins be diagnosed as having acute myocardial infarction (AMI), even when creatine kinase (CK) and CK-MB are within the normal range. 1 Alpert J.S. Thygesen K. Antman E. Bassand J.P. Myocardial infarction redefined—a consensus document of The Joint European Society of Cardiology/American College of Cardiology Committee for the redefinition of myocardial infarction. J Am Coll Cardiol. 2000; 36: 959-969 Abstract Full Text Full Text PDF PubMed Scopus (3795) Google Scholar The short-term risk of death or myocardial infarction in patients with unstable coronary syndromes and elevated levels of cardiac troponin but normal CK and CK-MB levels is as high as 20%. 2 Ottani F. Galvani M. Nicolini F.A. Ferrini D. Pozzati A. Di Pasquale G. Jaffe A.S. Elevated cardiac troponin levels predict the risk of adverse outcome in patients with acute coronary syndromes. Am Heart J. 2000; 140: 917-927 Abstract Full Text Full Text PDF PubMed Scopus (221) Google Scholar Data on the long-term (2-year) mortality of these patients with small AMIs, however, is limited. We designed a prospective historical cohort study to determine the long-term prognostic value of patients with clinical unstable angina pectoris (UAP), elevated troponin I, and normal CK and CK-MB levels.