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Are the Cannabinoids Involved in Bony Fish Reproduction?

2005; Wiley; Volume: 1040; Issue: 1 Linguagem: Inglês

10.1196/annals.1327.041

1749-6632

Erika Cottone, Ezio Campantico, Alda Guastalla, STEFANIA ARAMU, A.M. Polzonetti‐Magni, Mariafosca Franzoni,

Diet, Metabolism, and Disease

Following the discovery of two CB1 genes in the fish Fugu rubripes, investigations on the phylogeny of endocannabinoids have indicated that this system is highly conserved. Our study demonstrated that CB1 receptors are expressed in the CNS and gonads of two teleosts, Carassius auratus and Pelvicachromis pulcher, and they show a high percentage of sequence identity with Fugu rubripes CB(1A) and Danio rerio CB1. By means of immunohistochemistry for CB1, sGnRH, and TH, we found a codistribution of these signaling molecules in the basal telencephalon/preoptic area, which are key centers for gonadotropic regulation. We therefore suggest that endocannabinoids are possibly involved in modulating fish reproduction at both the central and peripheral levels.