Make it or break it: the role of ubiquitin-dependent proteolysis in cellular regulation
1995; Elsevier BV; Volume: 5; Issue: 11 Linguagem: Inglês
10.1016/s0962-8924(00)89102-3
ISSN1879-3088
Autores Tópico(s)Autophagy in Disease and Therapy
ResumoEffective regulation of the concentration of a protein in the cell requires rapid protein degradation. Until recently, it was widely believed that intracellular proteolysis was largely confined to the turnover o f damaged, or otherwise abnormal, proteins. Recently, however, the role o f protein degradation in cellular regulation has gained centre stage, and ubiquitin/proteasome-dependent proteolysis has been shown to play a key role in processes as diverse as embryonic development, transcription and the cell cycle.
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