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Anti-HIV-1 Protease Activity of Lanostane Triterpenes from the Vietnamese Mushroom Ganoderma colossum

2008; American Chemical Society; Volume: 71; Issue: 6 Linguagem: Inglês

10.1021/np8001139

1520-6025

Riham Salah El Dine, Ali M. El-Halawany, Chao‐Mei Ma, Masao Hattori,

Chemical synthesis and alkaloids

Four new lanostane triterpenes, colossolactone V (1), colossolactone VI (2), colossolactone VII (3), and colossolactone VIII (4), were isolated from the fruiting bodies of the Vietnamese mushroom Ganoderma colossum, together with the known compound colossolactone E (5). The structures of 1−4 were assigned on the basis of spectroscopic evidence, and their absolute configurations were determined by CD spectroscopy and the Mosher ester method. Compounds 1−5, as well as two previously isolated compounds [schisanlactone A (6) and colossolactone G (7)] from the same mushroom, were evaluated for inhibition of HIV-1 protease, with IC50 values for the most potent compounds ranging from 5 to 13 µg/mL.