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Effects of phosphoethanolamine and ethanolamine on growth of mammary carcinoma cells in culture

1981; Elsevier BV; Volume: 136; Issue: 1 Linguagem: Inglês

10.1016/0014-4827(81)90045-8

1090-2422

Tamiko Kano‐Sueoka, Janice E. Errick,

Cannabis and Cannabinoid Research

Phosphoethanolamine (PEtn) was previously shown to be a potent mitogen for a rat mammary carcinoma cell line, 64-24. The objective of this study was to elucidate the role of phosphoethanolamine as a mitogen. The growth stimulatory effect of various compounds related to PEtn was examined, and ethanolamine (Etn) and compounds whose structures resembled Etn were also found to be active. Among several neoplastic mammary epithelial cell lines of human and rat tested, a human line, T47-D, gave a positive growth response to phosphoethanolamine. The results suggest that a positive growth response to PEtn is correlated with growth response of a cell line to prolactin in culture. PEtn and Etn (10−6 M) added to the medium incorporated efficiently into cellular phosphatidylethanolamine. After 3–4 days in culture more than 50% of the cellular phosphatidylethanolamine appeared to be derived from exogenous PEtn or Etn. Moreover, phosphatidylethanolamine content in phospholipid became three times higher than that without Etn in the medium.