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Human Induced Pluripotent Stem Cells: The Past, Present, and Future

2011; Wiley; Volume: 89; Issue: 5 Linguagem: Inglês

10.1038/clpt.2011.37

1532-6535

Samer M. I. Hussein, Kristina Vintersten Nagy, András Nagy,

Biomedical Ethics and Regulation

A major breakthrough in the past 5 years is the development of the ability to reprogram somatic cells to pluripotency. It has rejuvenated the field of stem cell research, providing regenerative medicine with new possibilities. In this paper, we discuss the progress made in the reprogramming field with focus on induction methodologies, the use of induced pluripotent stem cells (iPSCs) for drug discovery, and issues and precautions related to their use in regenerative medicine. Clinical Pharmacology & Therapeutics (2011) 89 5, 741–745. doi:10.1038/clpt.2011.37