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Radiation-induced survival responses promote immunogenic modulation to enhance immunotherapy in combinatorial regimens

2014; Landes Bioscience; Volume: 3; Issue: 5 Linguagem: Inglês

10.4161/onci.28643

2162-402X

Sofia R. Gameiro, Andressa Ardiani, Anna Kwilas, James W. Hodge,

CAR-T cell therapy research

Tumor cells that survive radiation are more sensitive to T-cell-mediated lysis due to a spectrum of biological adaptations to cellular stress (defined as immunogenic modulation), including enhanced antigen processing and cell-surface presence of calreticulin. This mechanism can be exploited to maximize clinical benefit in patients receiving radiotherapy plus immunotherapy.