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Biological Expression of Steroid Hormone Receptors in Primary Meningioma Cells in Monolayer Culture

1984; Lippincott Williams & Wilkins; Volume: 7; Issue: 4 Linguagem: Inglês

10.1097/00002826-198412000-00019

1537-162X

David T. Zava, Thomas-Marc Markwalder, Regula Markwalder,

Pituitary Gland Disorders and Treatments

Primary meningiomas have been grown in monolayer culture and tested for the presence of steroid hormone receptors and sensitivity to various steroids and steroid antagonists. None of the 10 solid tumors or the primary cultures derived from them contained estrogen receptors, either in the cytoplasm or in the nucleus. Progesterone receptors were present in 50-70% of the solid tumors and some of the primary cultures. Four of four and five of five primary cultures contained, respectively, androgen and glucocorticoid receptors. When one of the primary cultures was tested for growth sensitivity to estrogen, tamoxifen, progesterone, hydrocortisone, and dihydrotestosterone, the last two had noticeable stimulatory effects on growth by day 5. Interestingly, only androgen and glucocorticoid receptors were present in the primary tumor cells in culture, suggesting that these receptors mediated the effects of their respective hormones on growth.