Advanced Squamous Carcinoma of the Head and Neck: A Preliminary Report of Neoadjuvant Chemotherapy With Cisplatin, Bleomycin, and Methotrexate
1984; American Medical Association; Volume: 110; Issue: 4 Linguagem: Inglês
10.1001/archotol.1984.00800300033007
ISSN1538-361X
AutoresThomas J. Ervin, Ralph R. Weichselbaum, Richard L. Fabian, D. Miller, Colleen M. Norris, Marshall R. Posner, Christopher M. Rose, Peter B. Lockhart, Stephanie Tuttle, John Macintyre, E Frei,
Tópico(s)Head and Neck Surgical Oncology
Resumo• Between Oct 1, 1979 and Aug 1, 1982, 93 patients with advanced squamous carcinoma of the head and neck were given neoadjuvant treatment with cisplatin, bleomycin sulfate, and methotrexate before standard local treatment. Ninety-three patients were evaluable for response. The response rates were as follows: complete response, 24%; partial response, 64%; and no response, 12%. Differences in primary tumor site, performance status at presentation, histologic grade, and tumor size did not correlate with response to this chemotherapy. For patients achieving notable tumor reduction to 2 cm or less, standard local treatment with either surgery plus radiotherapy or high-dose radiotherapy alone was effective in controlling local disease. For patients with larger tumor masses following neoadjuvant chemotherapy, surgical resectability appeared to improve local control rates. In our series, patients not receiving maximal standard local treatment often had relapse of local disease despite favorable responses to chemotherapy. ( Arch Otolaryngol 1984;110:241-245)
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