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Metabolic alkalosis in patients with hypercalcemia

1965; Elsevier BV; Volume: 14; Issue: 11 Linguagem: Inglês

10.1016/0026-0495(65)90086-7

1532-8600

H. Heinemann,

Bone health and osteoporosis research

Abstract Hypercalcemia in patients with various neoplasms is not infrequently associated with metabolic alkalosis. This acid-base imbalance occurs in the absence of any of the known alkalosis-producing complications such as hydrogen ion loss, potassium depletion, chloride deficiency, or contraction of the extracellular fluid volume. It is postulated that the alkalosis of hypercalcemia, documented in 20 patients and presented here, is due to greater availability of the buffering capacity of the skeleton secondary to either bone destruction or increased bone turnover.