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Clomipramine and Sexual Function in Men with Premature Ejaculation and Controls

1996; Lippincott Williams & Wilkins; Volume: 156; Issue: 4 Linguagem: Inglês

10.1016/s0022-5347(01)65576-9

1527-3792

Stefan M. Haensel, David L. Rowland, Khalid T. H. K. Kallan, Koos Slob,

Hormonal and reproductive studies

No AccessJournal of UrologyClinical Urology: Original Article1 Oct 1996Clomipramine and Sexual Function in Men with Premature Ejaculation and Controls Stefan M. Haensel, David L. Rowland, Khalid T.H.K. Kallan, and Koos A. Slob Stefan M. HaenselStefan M. Haensel , David L. RowlandDavid L. Rowland , Khalid T.H.K. KallanKhalid T.H.K. Kallan , and Koos A. SlobKoos A. Slob View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)65576-9AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We determined whether clomipramine taken as needed increases ejaculation latency in men with premature ejaculation and controls. Materials and Methods: The study included 8 patients with primary premature ejaculation, 6 with premature ejaculation and erectile dysfunction, and 8 controls. A prospective, double-blind, placebo controlled, crossover design was used that included 2, 3-week periods with clomipramine and placebo. During treatment phases subjects took either 25 mg. clomipramine or placebo as needed, that is 12 to 24 hours before anticipated sexual activity (coitus or masturbation). Subjects also visited the laboratory during these phases for evaluation of sexual response using visual erotic stimulation with and without vibration to the penis. Daily logs of sexual activities were maintained during treatment phases. Results: Clomipramine significantly increased the latency to ejaculation during sexual activity (coitus or masturbation) from approximately 2 to 8 minutes in men with primary premature ejaculation. There were no significant effects in controls and men with premature ejaculation plus erectile dysfunction. Laboratory assessment indicated that men with primary premature ejaculation were better able to control ejaculatory response with clomipramine therapy. In these men clomipramine also resulted in increased satisfaction with sex life and relationship. Clomipramine inhibited nocturnal penile tumescence in all subjects. Conclusions: Clomipramine (25 mg. as needed) effectively increases ejaculatory latency in men with primary premature ejaculation, while treatment is not effective in those with premature ejaculation and erectile dysfunction. References 1 : Pharmacologic treatment of rapid ejaculation. Psychiatr. Clin. N. Amer.1995; 18: 85. Google Scholar 2 : Pharmacologic treatment for rapid ejaculation: preliminary strategies, concerns and questions. Sex. Marital Ther.1995; 10: 247. Google Scholar 3 : A double-blind crossover trial of clomipramine for rapid ejaculation in 15 couples. J. Clin. Psychiatr.1995; 56: 402. 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Google Scholar Departments of Endocrinology and Reproduction, and Urology, Erasmus University and Dijkzigt Academic Hospital, Rotterdam, The Netherlands, and Department of Psychology, Valparaiso University, Valparaiso, Indiana.© 1996 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byChoi J, Kang S, Lee D, Kim Y, Jeon J, Choi W and Kim S (2018) Efficacy and Safety of On Demand Clomipramine for the Treatment of Premature Ejaculation: A Multicenter, Randomized, Double-Blind, Phase III Clinical TrialJournal of Urology, VOL. 201, NO. 1, (147-153), Online publication date: 1-Jan-2019.WALDINGER M (2018) The Neurobiological Approach to Premature EjaculationJournal of Urology, VOL. 168, NO. 6, (2359-2367), Online publication date: 1-Dec-2002.Kim S and Seo K (2018) EFFICACY AND SAFETY OF FLUOXETINE, SERTRALINE AND CLOMIPRAMINE IN PATIENTS WITH PREMATURE EJACULATION: A DOUBLE-BLIND, PLACEBO CONTROLLED STUDYJournal of Urology, VOL. 159, NO. 2, (425-427), Online publication date: 1-Feb-1998. Volume 156Issue 4October 1996Page: 1310-1315 Advertisement Copyright & Permissions© 1996 by American Urological Association, Inc.MetricsAuthor Information Stefan M. Haensel More articles by this author David L. Rowland More articles by this author Khalid T.H.K. Kallan More articles by this author Koos A. Slob More articles by this author Expand All Advertisement PDF downloadLoading ...