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Distribution of different sized microspheres in experimental hepatic tumours

1987; Pergamon Press; Volume: 23; Issue: 1 Linguagem: Inglês

10.1016/0277-5379(87)90416-0

1878-5980

Veronica M. Meade, Mark A. Burton, Bruce N. Gray, Greg W. Self,

Organ Transplantation Techniques and Outcomes

The extent of embolization of different sized radioactive microspheres in experimental tumours and the homogeneity of their distribution in normal liver was examined in 25 rats. The ratio of arterially introduced microspheres lodging in tumour tissue compared to the surrounding normal hepatic parenchyma was measured for 15, 32.5 and 50 μm diameter tracer microspheres. The mean tumour to liver arterial perfusion ratio (T/L) for 15 and 32.5 μm spheres was approximately 3:1 in both cases and there was no significant difference between these values (P > 0.05). However, 50 μm microspheres did not preferentially lodge in malignant tissue (mean T/L ratio 1 : 1). The homogeneity of distribution of microspheres embolizing in the normal liver tissue was assessed for each microsphere size. As microsphere diameter increased from 15 to 50 μm, microspheres lodged more evenly throughout the liver substance. For 15 μm microspheres the coefficient of variation was 55.5% ± 8.3 and 32.5 μm microspheres distributed with a coefficient of 35% ± 16.8 while 50 μm spheres distributed most evenly with a coefficient of 19.7% ± 6.8.