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Cyclobutane Dimers from the Colombian Medicinal Plant Achyrocline b ogotensis

2005; American Chemical Society; Volume: 68; Issue: 4 Linguagem: Inglês

10.1021/np040187y

1520-6025

Takaaki Sagawa, Yoshihisa Takaishi, Yoshinori Fujimoto, Carmenza Duque, Coralia Osorio, Freddy A. Ramos, Cristina Garzón, Mitsunobu Sato, Masato Okamoto, Tetsuya Oshikawa, Sharif Ahmed,

Cholinesterase and Neurodegenerative Diseases

Five cyclobutane dimers, achyrodimers A-E (1-5), along with 11 known compounds were isolated from the methanol extract of the Colombian medicinal plant Achyrocline bogotensis. Their structures were elucidated by spectroscopy. Several of these compounds were screened for cytokine-inducing activity in human peripheral blood mononuclear cells.