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Collagen development in heart and skin of the chick embryo

1967; Elsevier BV; Volume: 140; Issue: 2 Linguagem: Inglês

10.1016/0005-2795(67)90473-4

1878-1454

J. Frederick Woessner, Reza I. Bashey, Robert J. Boucek,

Collagen: Extraction and Characterization

1.|The development of the collagenous framework was studied in the chick-embryo heart and skin. Collagen was detected in the heart on the 3rd day of development. The heart growth and collagen growth from the 5th to the 21st day of development can be described by continuous exponental functions. However, collagen increases more rapidly than heart weight as described by the relationship: Collagen = K (heart wet wt.)1.61 2.|A mechanical interpretation of the data suggests that the increasing proportion of collagen in the enlarging heart may be related to the increasing mechanical strength requirements of the enlarging heart. 3.|The amount of soluble collagen in the heart was found to be almost directly proportional to the net rate of collagen synthesis in the heart. 4.|Collagen growth in the skin does not follow a continuous exponential time curve. Rather, there is an abrupt increase in skin collagen concentration between the 12th and 17th days of development. 5.|This discontinuity in the synthesis of skin collagen points up the difficulty in attempting to relate soluble collagen content to the rate of growth of the organism or tissue.