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Effect of physicochemical properties of adhesive on the release, skin permeation and adhesiveness of adhesive-type transdermal drug delivery systems (a-TDD) containing silicone-based pressure-sensitive adhesives

1991; Elsevier BV; Volume: 76; Issue: 1-2 Linguagem: Inglês

10.1016/0378-5173(91)90346-p

1873-3476

Rohinton Toddywala, Katherine L. Ulman, Perry Walters, Yie W. Chien,

Drug Solubulity and Delivery Systems

Adhesive dispersion-type transdermal drug delivery (a-TDD) systems consisting of a monolayer of drug-loaded adhesive matrix were developed from three types of silicone-based pressure-sensitive adhesives. The adhesive polymers were tailored such that two of them were lipophilic (Bio-PSA® X7-2920 and Dow Corning® -355 Medical Adhesive) and one was relatively hydrophilic (E8086® adhesive) in nature. Three steroids viz., progesterone, testosterone and hydrocortisone, were used as model penetrants and their release from the a-TDD systems and permeation through skin were investigated. The adhesive properties of these systems were also studied. The partial and total solubility parameters of these adhesive polymers were also determined. The release of steroid molecules was observed to be a complex function of the physicochemical properties of the drug and polymer. The adhesiveness as determined from a standard peel test indicated that incorporation of the drug in higher drug loading doses results in a loss of adhesiveness. The results suggest that the chemical nature of the polymer is an important consideration when studying such adhesives for transdermal drug delivery.