Inhibitory action of novel aromatic diamine compound on lipopolysaccharide‐induced nuclear translocation of NF‐κB without affecting IκB degradation
2004; Wiley; Volume: 571; Issue: 1-3 Linguagem: Inglês
10.1016/j.febslet.2004.06.056
ISSN1873-3468
AutoresHyun-Mo Shin, Min-Hee Kim, Byung Hak Kim, Sang‐Hun Jung, Yeong Shik Kim, Hye Ji Park, Jin Tae Hong, Kyung Rak Min, Young Soo Kim,
Tópico(s)Genomics, phytochemicals, and oxidative stress
Resumo4‐Methyl‐ N 1 ‐(3‐phenyl‐propyl)‐benzene‐1,2‐diamine (JSH‐23) is a novel chemically synthetic compound. The aromatic diamine JSH‐23 compound exhibited inhibitory effect with an IC 50 value of 7.1 μM on nuclear factor (NF)‐κB transcriptional activity in lipopolysaccharide (LPS)‐stimulated macrophages RAW 264.7, and interfered LPS‐induced nuclear translocation of NF‐κB without affecting IκB degradation. This mechanism of action is very rare for controlling NF‐κB activation. Furthermore, the compound inhibited not only LPS‐induced expressions of tumor necrosis factor‐α, interleukin (IL)‐1β, IL‐6 and inducible nitric oxide synthase and cyclooxygenase‐2 but also LPS‐induced apoptosis of the RAW 264.7 cells.
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