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Synthesis and Structural Characterization of Hexacoordinate Silicon, Germanium, and Titanium Complexes of the E. coli Siderophore Enterobactin

2013; Wiley; Volume: 19; Issue: 32 Linguagem: Inglês

10.1002/chem.201301825

1521-3765

Todor Baramov, Karlijn Keijzer, Elisabeth Irran, Eva Mösker, Mu‐Hyun Baik, Roderich D. Süßmuth,

Chemical Synthesis and Characterization

Abstract The E. coli siderophore enterobactin, one of the strongest Fe III chelators known to date, is also capable of binding Si IV under physiological conditions. We report on the synthesis and structural characterization of the tris(catecholate) Si IV –enterobactin complex and its Ge IV and Ti IV analogues. Comparative structural analysis, supported by quantum‐chemical calculations, reveals the correlation between the ionic radius and the structural changes in enterobactin upon complexation.