Artigo Revisado por pares

Growth Hormone and Insulin-Like Growth Factor I Responses to Moderate Submaximal Acute Physical Exercise in Man: Effects of Octreotide, a Somatostatin Analogue, Administration

1997; Thieme Medical Publishers (Germany); Volume: 18; Issue: 04 Linguagem: Inglês

10.1055/s-2007-972630

ISSN

1439-3964

Autores

Luigi Di Luigi, F. Conti, Alessandra Ferri Casini, Laura Guidetti, G. Zezze, Fabio Pigozzi, Giovanni Spera, G. Fortunio, Francesco Romanelli,

Tópico(s)

Pituitary Gland Disorders and Treatments

Resumo

We evaluated growth hormone (GH) and insulin-like growth factor I (IGF-I) response to moderate submaximal acute short-term physical exercise under basal conditions and after the administration of octreotide, a somatostatin analogue (5A), in a double-blind, counter-balanced experimental protocol. Seven untrained male volunteers performed two identical (exercise tests, each on a treadmill (2.5 % slope) for 30 minutes ((min) at 60 % of VO2max. Before starting the exercise test all the subjects received a single administration of placebo or octreotide and vice versa at two different sessions. Plasma GH, IGF-I and lactate assays were evaluated before starting, during, at the end and in the recovery phase. In the placebo-treated group GH rose significantly both during exercise and recovery whereas no significant modifications in IGF-I levels were observed. SA administration inhibited the exercise-dependent GH secretion, which showed a small rise only during exercise and returned to basal levels during recovery. In the same group, IGF-I decreased significantly after exercise compared to basal values. The results suggest that 1) in our experimental conditions acute physical exercise at aerobic threshold does not modify IGF-I concentration 2) SA is able to inhibit the exercise-dependent GH secretion and to decrease post-exercise IGF-I concentration.

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