Drug delivery by a self-assembled DNA tetrahedron for overcoming drug resistance in breast cancer cells
2013; Royal Society of Chemistry; Volume: 49; Issue: 20 Linguagem: Inglês
10.1039/c3cc38693g
ISSN1364-548X
AutoresKyoung-Ran Kim, Da-Rae Kim, Taemin Lee, Ji Young Yhee, Byeong‐Su Kim, Ick Chan Kwon, Dae‐Ro Ahn,
Tópico(s)RNA Interference and Gene Delivery
ResumoA DNA tetrahedron is employed for efficient delivery of doxorubicin into drug-resistant breast cancer cells. The drug delivered with the DNA nanoconstruct is considerably cytotoxic, whereas free doxorubicin is virtually non-cytotoxic for the drug-resistant cells. Thus, the DNA tetrahedron, made of the inherently natural and biocompatible material, can be a good candidate for the drug carrier to overcome MDR in cancer cells.
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