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DIRECT INHIBITION OF GASTRIC ACID AND PEPSIN SECRETION BY GROWTH-HORMONE RELEASE-INHIBITING HORMONE IN CATS

1975; Elsevier BV; Volume: 305; Issue: 7912 Linguagem: Inglês

10.1016/s0140-6736(75)91686-4

1474-547X

A Gómez-Pan, Margittá Albinus, J D Reed, B. Shaw, R. Hall, G. M. Besser, D.H. Coy, Abba J. Kastin, Andrew V. Schally,

Receptor Mechanisms and Signaling

Growth-hormone release-inhibiting hormone (G.H.-R.I.H.) inhibited gastric acid and pepsin secretion in response to pentagastrin and food stimulation in cats. This effect is mediated by a direct action on the parietal and peptic cells. No evidence of a post-inhibitory acid or pepsin secretory rebound was obtained. Thus a compound of hypothalamic origin can exert a direct effect on exocrine secretion. In view of its widespread actions and its presence in relatively high concentrations in various organs apart from the hypothalamus, G.H.-R.I.H. might also be regarded as a factor responsible for local coordination of endocrine and exocrine secretion.