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Arterial baroreceptor responses to intraaortic balloon assistance

1971; Elsevier BV; Volume: 11; Issue: 8 Linguagem: Inglês

10.1016/0022-4804(71)90146-6

1095-8673

Nils A. Normann, John H. Kennedy,

Cardiac Arrhythmias and Treatments

Alteration in arterial baroreceptor output (BRO) by intraaortic balloon assistance (IABA) was studied in acute experiments in normal dogs. Baroreceptor impulses originating in the aortic arch and in the carotid sinus were recorded. Without balloon assistance a single BRO volley accompanies each pulse wave. IABA produced two sharply delineated BRO volleys, one caused by left ventricular ejection and the other by diastolic pressure augmentation. Although BRO during cardiac systole fell, the addition of a second BRO volley during balloon inflation in diastole led to a net increase in BRO. The magnitude of BRO in each phase responded to changes in balloon inflation pressure and in timing of events. As expected from the known rate sensitivity of baroreceptors, the electroneurographic wave form correlated poorly with simultaneous pressure wave forms. When recorded simultaneously, BRO from aortic arch and carotid sinus baroreceptors responded similarly to IABA. The marked alterations of BRO observed in this study emphasize the need to consider system factors in the design and operation of mechanical circulatory devices; induced neurohumoral responses are likely to contribute significantly to the final therapeutic result.