Influence of insulin and 12-O-tetradecanoylphorbol-13-acetate (TPA) on influenza virus multiplication
1986; Elsevier BV; Volume: 6; Issue: 3 Linguagem: Inglês
10.1016/0168-1702(86)90076-6
ISSN1872-7492
AutoresChristoph Scholtissek, Karin Müller, Sibylle Herzog,
Tópico(s)Influenza Virus Research Studies
ResumoInsulin and 12-O-tetradecanoylphorbol-13-acetate (TPA) interfere with the multiplication of fowl plague virus, an influenza A virus, in primary chick embryo cells. Specifically the production of the viral glycoproteins hemagglutinin and neuraminidase are affected by the drugs. A decrease or omission of glucose from the culture medium enhances this effect, which is in agreement with the idea that these drugs act on virus replication via a shortage of glucose in the host cell. Virus replication in cells of different organs is affected to different extents by insulin and TPA.
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