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LIDOCAINE PREVENTS NOXIOUS EXCITATION OF BLADDER AFFERENTS INDUCED BY INTRAVESICAL CAPSAICIN WITHOUT INTERFERING WITH THE ENSUING SENSORY DESENSITIZATION: AN EXPERIMENTAL STUDY IN THE RAT

1998; Lippincott Williams & Wilkins; Volume: 159; Issue: 2 Linguagem: Inglês

10.1016/s0022-5347(01)63985-5

1527-3792

António Avelino, Francisco Cruz, Antonio Coimbra,

Neuropeptides and Animal Physiology

No AccessJournal of UrologyInvestigative Urology1 Feb 1998LIDOCAINE PREVENTS NOXIOUS EXCITATION OF BLADDER AFFERENTS INDUCED BY INTRAVESICAL CAPSAICIN WITHOUT INTERFERING WITH THE ENSUING SENSORY DESENSITIZATION: AN EXPERIMENTAL STUDY IN THE RAT Antonio Avelino, Francisco Cruz, and Antonio Coimbra Antonio AvelinoAntonio Avelino More articles by this author , Francisco CruzFrancisco Cruz Requests for reprints: Institute of Histology and Embryology, Faculty of Medicine of Porto, 4200-Porto, Portugal. More articles by this author , and Antonio CoimbraAntonio Coimbra More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)63985-5AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: The effects of the local anesthetic lidocaine on the noxious excitation and subsequent desensitization of bladder sensory fibers, produced by intravesical capsaicin, were evaluated through c-fos activation in the spinal cord. Materials and Methods: Noxious excitation was demonstrated by counting Fos-immunoreactive (IR) cells occurring in the rat spinal cord 2 hours after intravesical administration of 1 mM. capsaicin, preceded or not by 2% lidocaine. Desensitization was studied by comparing the number of Fos-IR cells induced by 1% acetic acid in rats treated 24 hours before with 1 mM. intravesical capsaicin preceded or not by 2% lidocaine. Results: Lidocaine instilled previously markedly reduced the number of Fos-IR spinal cells responding to capsaicin-induced bladder afferent excitation. Numbers of Fos-IR cells induced by acetic acid instillation in bladders desensitized by capsaicin administrated 24 hours before were not changed by lidocaine application prior to capsaicin. Conclusions: These findings suggest that local anesthetic pretreatment of the bladder with lidocaine reduces the capsaicin-induced noxious excitation of the sensory fibers without decreasing their subsequent desensitization. References 1 : Behavioral characterization of the excitatory and desensitizing effects of intravesical capsaicin and resiniferatoxin in the rat.. Pain.1993; 55: 205. Google Scholar 2 : Desensitization follows excitation of bladder primary afferents by intravesical capsaicin, as shown by c-fos activation in the rat spinal cord.. Pain.1996; 64: 553. 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Google Scholar Institute of Histology and Embryology, Faculty of Medicine of Porto, IBMC of University of Porto and Department of Urology, Hospital Sao Joao, Porto, Portugal.© 1998 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byGiannantoni A, Di Stasi S, Stephen R, Navarra P, Scivoletto G, Mearini E and Porena M (2018) Intravesical Capsaicin Versus Resiniferatoxin In Patients With Detrusor Hyperreflexia: A Prospective Randomized StudyJournal of Urology, VOL. 167, NO. 4, (1710-1714), Online publication date: 1-Apr-2002.LAPOINTE S, WANG B, KENNEDY W and SHORTLIFFE L (2018) THE EFFECTS OF INTRAVESICAL LIDOCAINE ON BLADDER DYNAMICS OF CHILDREN WITH MYELOMENINGOCELEJournal of Urology, VOL. 165, NO. 6 Part 2, (2380-2382), Online publication date: 1-Jun-2001.WANG Y and HASSOUNA M (2018) NEUROMODULATION REDUCES C-FOS GENE EXPRESSION IN SPINALIZED RATS: A DOUBLE-BLIND RANDOMIZED STUDYJournal of Urology, VOL. 163, NO. 6, (1966-1970), Online publication date: 1-Jun-2000. Volume 159Issue 2February 1998Page: 567-570 Advertisement Copyright & Permissions© 1998 by American Urological Association, Inc.MetricsAuthor Information Antonio Avelino More articles by this author Francisco Cruz Requests for reprints: Institute of Histology and Embryology, Faculty of Medicine of Porto, 4200-Porto, Portugal. More articles by this author Antonio Coimbra More articles by this author Expand All Advertisement PDF downloadLoading ...