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Fluoroquinolone Resistance in Haemophilus influenzae Is Associated with Hypermutability

2007; American Society for Microbiology; Volume: 51; Issue: 4 Linguagem: Inglês

10.1128/aac.01437-06

1098-6596

Marı́a Pérez-Vázquez, Federico Román, Silvia García-Cobos, José Campos,

Bacterial Infections and Vaccines

Forty-three percent (12/28) of ciprofloxacin (CIP)-nonsusceptible respiratory isolates of Haemophilus influenzae were hypermutable, compared with 8.5% (3/35) in the CIP-susceptible control group (P=0.002). CIP-nonsusceptible mutants were obtained with hypermutable strains only; these mutants developed three resistance mechanisms in a step-by-step process: target modifications, loss of a porin protein, and increased efflux.