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BIBTEX RIS

The hemorrhagic syndrome of leptospirosis: an experimental study in guinea pigs

1995; Brazilian Society of Tropical Medicine; Volume: 28; Issue: 3 Linguagem: Inglês

10.1590/s0037-86821995000300002

ISSN

1678-9849

Autores

João José Pereira da Silva, Bernardino Alves de Souza Netto, Walter Lilembaum, Maria Erbene Amorim Melo Alvim, Albanita V. Oliveira,

Tópico(s)

Leptospirosis research and findings

Resumo

The hemorrhagic syndrome of leptospirosis was studied in guinea pigs. The study correlates hematological, histopathological and immunohistochemical alterations in sixty animals inoculated by the intraperitoneal route with lml of the culture of virulent strain of Leptospira interrogans serovar copenhageni. Leptospirae antigens were detected by immunoperoxidase, chiefly in liver, kidney and heart muscle capillaries. Possible pathogenic mechanisms responsible for hemorrhagic syndrome are discussed with emphasis on toxic and anoxic attacks causing damage to endothelia, platelet depletion and alterations to hemostasia rates: prothrombin time [FT], partial thromboplastin time [PIT] and fibrinogen concentrations. Tide clinical-laboratoiy picture is compatible with the histopathological observation of disseminated intravascular coagulation [D1C] in most of the guinea pigs from day 4 of infection.

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