Produção Nacional
Secondary acute myeloid leukemia with a t(1;11)(q23;p15) in an adolescent treated for testicular sarcoma
2006; Elsevier BV; Volume: 169; Issue: 1 Linguagem: Inglês
10.1016/j.cancergencyto.2006.02.008
ISSN1873-4456
AutoresEliane Maria Azevedo Soares, Neide Santos, Bethânia de Araújo Silva Amaral, Maria Luíza Macedo Silva, Ednalva Pereira Leite, Mariluze Oliveira Silva, Maria Tereza Cartaxo Muniz, Raul C. Ribeiro, Vera Lúcia Lins de Morais, Terezinha de Jesus Marques-Salles,
Tópico(s)Genomics and Chromatin Dynamics
ResumoChromosomal rearrangements in the chromosomal region 11p15 have been recurrently involved in secondary hematopoietic malignancies [ [1] Lam D.H. Aplan P.D. NUP98 gene fusions in hematologic malignancies. Leukemia. 2001; 15: 1689-1695 Crossref PubMed Scopus (85) Google Scholar ]. Molecular studies have shown that the 11p15 recurrent translocations in primary and secondary hematopoietic malignancies target the nucleoporin (NUP98) gene [ 2 Nakamura T. Yamazaki Y. Hatano Y. Miura I. NUP98 is fused to PMX1 homeobox gene in human acute myelogenous leukemia with chromosome translocation t(1;11)(q23;p15). Blood. 1999; 94: 741-747 Crossref PubMed Google Scholar , 3 Nakamura T. Largaespada D.A. Lee M.P. Johnson L.A. Ohyashiki K. Toyama K. Chen S.J. Willman C.L. Chen I.M. Feinberg A.P. Jenkins N.A. Copeland N.G. Shaughnessy Jr., J.D. Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukemia. Nat Genet. 1996; 12: 155-158 Google Scholar , 4 Hatano Y. Miura I. Nakamura T. Yamazaki Y. Takahashi N. Miura A.B. Molecular heterogeneity of the NUP98/HOXA9 fusion transcript in myelodysplastic syndromes associated with t(7;11)(p15;p15). Br J Haematol. 1999; 107: 600-604 Crossref PubMed Scopus (37) Google Scholar , 5 Nishiyama M. Arai Y. Tsunematsu Y. Kobayashi H. Asami K. Yabe M. Kato S. Oda M. Eguchi H. Ohki M. Kaneko Y. 11p15 translocations involving the NUP98 gene in childhood therapy-related acute myelogenous leukemia/myelodysplastic syndrome. Genes Chromosomes Cancer. 1999; 26: 215-220 Crossref PubMed Scopus (66) Google Scholar , 6 Mecucci C. La Starza R. Negrini M. Sabbioni S. Crescenzi B. Leoni P. Di Raimondo F. Krampera M. Cimino G. Tafuri A. Cuneo A. Vitale A. Foà R. t(4;11)(q21;p15) translocation involving NUP98 and RAP1GDS1 genes: characterization of a new subset of T acute lymphoblastic leukaemia. Br J Haematol. 2000; 109: 788-793 Crossref PubMed Scopus (32) Google Scholar ]. These chromosomal rearrangements lead to the fusion of the 5' portion of NUP98 with coding sequences from partner genes, which include Hox and non-Hox genes. NUP98 encodes a 98-kD nuclear pore transport protein that mediates the transport of proteins and RNA between the nucleus and cytoplasm. The recurrent rearrangement between NUP98 and several partner genes suggests that the NUP98 locus is vulnerable to genotoxic-induced chromosomal recombination, such as those observed in the MLL locus. In contrast to MLL, however, NUP98 has not been implicated in blood cell development. To date, diverse partner genes in several chromosomes have been targeted in rearrangements involving 11p15; however, the 1q23 chromosomal region has been reported previously in two cases of secondary acute myeloid leukemia (s-AML), and both were in adults [ 7 Hatano Y. Miura I. Kume M. Miura A.B. Translocation (1;11)(q23;p15), a novel simple variant of translocation (7;11)(p15;p15), in a patient with AML (M2) accompanied by non-Hodgkin lymphoma and gastric cancer. Cancer Genet Cytogenet. 2000; 117: 19-23 Abstract Full Text Full Text PDF PubMed Scopus (6) Google Scholar , 8 Kobzev Y.N. Martinez-Climent J. Lee S. Chen J. Rowley J.D. Analysis of translocations that involve the NUP98 gene in patients with 11p15 chromosomal rearrangements. Genes Chromosomes Cancer. 2004; 41: 339-352 Crossref PubMed Scopus (32) Google Scholar ].
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