Acquired Type I von Willebrand's Disease Associated with Highly Substituted Hydroxyethyl Starch
2001; Massachusetts Medical Society; Volume: 345; Issue: 8 Linguagem: Inglês
10.1056/nejm200108233450818
ISSN1533-4406
AutoresA.‐P. Jonville‐Béra, E. Autret‐Leca, Yves Gruel,
Tópico(s)Blood properties and coagulation
ResumoTo the Editor: High-molecular-weight hydroxyethyl starches (hetastarches) can cause acquired type I von Willebrand's disease.1 A case has also occurred after treatment with medium-molecular-weight hydroxyethyl starches (pentastarches).2 We analyzed all patients with hemostatic disorders that occurred during treatment with pentastarch (Elohes and Hesteril, Fresenius, Paris; and Lomol, Dupont, Wilmington, Del.) and that were spontaneously reported to the 31 French regional drug-monitoring centers. Nine cases of hemostatic disorders were reported between 1990 and 1997 (Table 1). All patients were treated with Elohes as hemodilution therapy (for vasospasm secondary to subarachnoid hemorrhage). Of the nine patients, six had a diagnosis of acquired . . .
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