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The Intracellular Signaling Network as a Target for Ethanol

1998; Wiley; Volume: 22; Issue: s5 Linguagem: Inglês

10.1111/j.1530-0277.1998.tb04007.x

1530-0277

Jan B. Hoek, Boris Ν. Kholodenko,

Neurotransmitter Receptor Influence on Behavior

Alcoholism: Clinical and Experimental ResearchVolume 22, Issue s5 p. 224S-230S The Intracellular Signaling Network as a Target for Ethanol Jan B. Hoek, Corresponding Author Jan B. Hoek Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania.Reprint requests: Jan B. Hoek, Ph.D., Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, JAH Room 26, 1020 Locust Street, Philadelphia, PA 19107.Search for more papers by this authorBoris N. Kholodenko, Boris N. Kholodenko Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania.Search for more papers by this author Jan B. Hoek, Corresponding Author Jan B. Hoek Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania.Reprint requests: Jan B. Hoek, Ph.D., Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, JAH Room 26, 1020 Locust Street, Philadelphia, PA 19107.Search for more papers by this authorBoris N. Kholodenko, Boris N. Kholodenko Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania.Search for more papers by this author First published: 30 May 2006 https://doi.org/10.1111/j.1530-0277.1998.tb04007.xCitations: 32 Presented at the Alcohol-Induced Immunopathology Symposium, New Orleans, LA, October 17–18, 1997. This work was supported by Grants AA07186, AA07215, AA08714, and AA11689 from the National Institute of Alcohol Abuse and Addiction. AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat REFERENCES 1 Raymond JR: Multiple mechanisms of receptor-G protein signaling specificity. Am J Physiol 269: F141–F158, 1995. 2 Schlessinger J: Cellular signaling by receptor tyrosine kinases. Harvey Lectures 89: 105–23, 1994. 3 Lewis TS, Shapiro PS, Ann NG: Signal transduction through MAP kinase cascades. Adv Cancer Res (in press), 1997. 4 Marte BM, Downward J: PKB/Akt: Connecting phosphoinositide 3-kinase to cell survival and beyond. Trends Biochem Sci 22: 355–358, 1997. 5 Wallach D, Boldin M, Varfolomeev E, Beyaert R, Vandenabeele P, Fiers W: Cell death induction by receptors of the TNF family: Towards a molecular understanding. FEBS Lett 410: 96–106, 1997. 6 Alevozopoulos A, Mermod N: Transforming growth factor β–The breaking open of a black box. Bioessays 19: 581–591, 1997. 7 Exton JH: Regulation of phosphoinositide phospholipases by hormones, neurotransmitters, and other agonists linked to G proteins. Annu Rev Pharmacol Toxicol 36: 481–509, 1996. 8 Rhee SG, Bae YS: Regulation of phosphoinositide-specific phospholipase C isozymes. J Biol Chem 272: 15045–15048, 1997. 9 Thomas AP, Bird GS, Hajnoczky G, Robb-Gaspers LD, Putney JW: Spatial and temporal aspects of cellular calcium signaling. FASEB J 10: 1505–1517, 1996. 10 Saso K, Higashi K, Nomura T, Hoshino M, Ito M, Moehren G, Hoek JB: Inhibitory effect of ethanol on hepatocyte growth factor-induced DNA synthesis and Ca2T mobilization in rat hepatocytes. Alcohol Clin Exp Res 20: 330A–334A, 1996. 11 Rooney TA, Sass EJ, Thomas AP: Agonist-induced cytosolic calcium oscillations originate from a specific locus in single hepatocytes. J Biol Chem 265: 10792–10796, 1990. 12 Berridge MJ, Dupont G: Spatial and temporal signalling by calcium. Curr Opin Cell Biol 6: 267–274, 1994. 13 Hoek JB, Nomura T, Higashi K: Ethanol and phospholipid dependent signal transduction: The view from the liver, in C Ailing, G Sun (eds): Alcohol, Cell Membranes and Signal Transduction in the Brain. New York , Plenum Press, 1993, pp 219–233. 14 Myers MG, White MF: Insulin signal transduction and the IRS proteins. Annu Rev Pharmacol Toxicol 36: 615–658, 1996. 15 Saso K, Moehren G, Higashi K, Hoek JB: Differential inhibition of epidermal growth factor signaling pathways in rat hepatocytes by long-term ethanol treatment. Gastroenterology 112: 2073–2088, 1997. 16 Daaka Y, Luttrell LM, Lefkowitz RJ: Switching of the coupling of the β2-adrenergic receptor to different G proteins by protein kinase A. Nature 390: 88–91, 1997. 17 Alroy I, Yarden Y: The ErbB signaling network in embryogenesis and oncogenesis: Signal diversification through combinatorial ligand-receptor interactions. FEBS Lett 410: 83–86, 1997. 18 Joseph SK: The inositol triphosphate receptor family. Cell Signal 8: 1–7, 1996. 19 Mochly-Rosen D: Localization of protein kinases by anchoring proteins: A theme in signal transduction. Science 268: 247–251, 1995. 20 Gordon AS, Yao L, Dohrman DP, Diamond I: Ethanol alters the subcellular localization of cAMP-dependent protein kinase and protein kinase C. Alcohol Clin Exp Res (in press). 21 Treisman R: Regulation of transcription by MAP kinase cascades. Curr Opin Cell Biol 8: 205–215, 1996. 22 Hoek JB, Taraschi TF, Rubin E: Functional implications of the interaction of ethanol with biologic membranes: Actions of ethanol on hormonal signal transduction systems. Sem Liver Dis 8: 36–46, 1988. 23 Hoek JB, Thomas AP, Rooney TA, Higashi K, Rubin E: Ethanol and signal transduction in the liver. FASEB J 6: 2386–2396, 1992. 24 Hoffman PL, Tabakoff B: Ethanol and guanine nucleotide binding proteins: A selective interaction. FASEB J 4: 2612–2622, 1990. 25 Crews FT, Morrow AL, Criswell H, Breese G: Effects of ethanol on ion channels. Int Rev Neurobiol 39: 283–367, 1996. 26 Gordon AS, Diamond I: Cellular and molecular neuroscience of alcoholism. Physiol Rev 77: 1–20, 1997. 27 Gordon LM, Mobley PW: Membrane lipids, membrane fluidity and enzyme activity, in RC Aloia, JM Boggs (eds): Membrane Fluidity in Biology, vol 4. Orlando , FL , Academic Press, 1985, pp 1–49. 28 Hoek JB, Thomas AP, Rubin R, Rubin E: Ethanol-induced mobilization of calcium by activation of phosphoinositide-specific phospholipase C in intact hepatocytes. J Biol Chem 262: 682–691, 1987. 29 Higashi K, Hoek JB: Ethanol causes desensitization of receptor-mediated phospholipase C activation in isolated hepatocytes. J Biol Chem 266: 2178–2190, 1991. 30 Rooney TA, Hager R, Rubin E, Thomas AP: Short chain alcohols activate guanine nucleotide-dependent phosphoinositidase C in turkey erythrocyte membranes. J Biol Chem 264: 6817–6822, 1989. 31 Rodriguez FD, Simonsson P, Gustavsson L, Ailing C: Mechanisms of adaptation to the effects of ethanol on activation of phospholipase C in NG 108-15 cells. Neuropharmacology 31: 1157–1164, 1992. 32 Grant KA, Lovinger DM: Cellular and behavioral neurobiology of alcohol: Receptor-mediated neuronal processes. Clin Neurosci 3: 155–164, 1995. 33 Covarrubias M, Vyas TB, Escobar L, Wei A: Alcohols inhibit a cloned potassium channel at a discrete saturable site. Insights into the molecular basis of general anesthesia. J Biol Chem 270: 19408–19416, 1995. 34 Solem M, McMahon T, Messing RO: Protein kinase A regulates inhibition of N- and P/Q-type calcium channels by ethanol in PC12 cells. J Pharmacol Exp Ther 282: 1487–1495, 1997. 35 Harris RA, McQuilkin SJ, Paylor R, Abeliovich A, Tonegawa S, Wehner JM: Mutant mice lacking the y isoform of protein kinase C show decreased behavioral actions of ethanol and altered function of y-aminobutyrate type A receptors. Proc Nat Acad Sci USA 92: 3658–3662, 1995. 36 Thurston AW, Shukla SD: Ethanol modulates epidermal growth factor-stimulated tyrosine kinase and phosphorylation of PLC-γ 1. Biochem Biophys Res Comm 185: 1062–1068, 1992. 37 Resnicoff M, Sell C, Ambrose D, Baserga R, Rubin R: Ethanol inhibits the autophosphorylation of the insulin-like growth factor 1 (IGF-1) receptor and IGF-1-mediated proliferation of 3T3 cells. J Biol Chem 268: 21777–21782, 1993. 38 Miyakawa T, Yagi T, Kitazawa H, Yasuda M, Kawai N, Tsuboi K, Niki H: Fyn-kinase as a determinant of ethanol sensitivity–Relation to NMDA-receptor function. Science 278: 698–701, 1997. 39 Mandrekar P, Catalano D, Szabo G: Alcohol-induced regulation of nuclear regulatory factor-K-B in human monocytes. Alcohol Clin Exp Res 21: 988–994, 1997. 40 Mochly-Rosen D, Chang FH, Cheever L, Kim M, Diamond I, Gordon AS: Chronic ethanol causes heterologous desensitization of receptors by reducing as messenger RNA. Nature 333: 848–850, 1988. 41 Fell DA: Metabolic control analysis: A survey of its theoretical and experimental development. Biochem J 286: 313–330, 1992. 42 Kholodenko BN, Westerhoff HV: The macroworld versus the microworld of biochemical regulation and control. Trends Biochem Sci 20: 52–54, 1995. 43 Kacser H, Burns JA: The control of flux, in DD Davies (ed): Rate Control of Biological Processes. London , Cambridge University Press, 1973, pp 65–104. 44 Kholodenko BN: How do external parameters control fluxes and concentrations of metabolites? An additional relationship in the theory of metabolic control. FEBS Lett 232: 383–386, 1988. 45 Kholodenko B, Hoek JB, Westerhoff HV, Brown GC: Quantification of information transfer via cellular signal transduction pathways. FEBS Lett 414: 430–434, 1997. 46 Brown GC, Hoek JB, Kholodenko BN: Why do protein kinase cascades have more than one level Trends Biochem Sci 22: 288, 1997. Citing Literature Volume22, Issues5August 1998Pages 224S-230S ReferencesRelatedInformation