Nanobubbles from Gas‐Generating Polymeric Nanoparticles: Ultrasound Imaging of Living Subjects
2009; Wiley; Volume: 49; Issue: 3 Linguagem: Inglês
10.1002/anie.200903841
ISSN1521-3773
AutoresEunah Kang, Hyun Su Min, Jaeyoung Lee, Moon Hee Han, Hyung Jun Ahn, In‐Chan Yoon, Kuiwon Choi, Kwangmeyoung Kim, Kinam Park, Ick Chan Kwon,
Tópico(s)Ultrasound and Cavitation Phenomena
ResumoAngewandte Chemie International EditionVolume 49, Issue 3 p. 524-528 Communication Nanobubbles from Gas-Generating Polymeric Nanoparticles: Ultrasound Imaging of Living Subjects† Eunah Kang Dr., Eunah Kang Dr. Biomedical Research Center, Korea Institute of Science and Technology, 39-1 Hawolgok-dong, Seongbuk-gu, Seoul 136 791 (Korea), Fax: (+82) 2-958-5909 These authors contributed equally to this work.Search for more papers by this authorHyun Su Min, Hyun Su Min Biomedical Research Center, Korea Institute of Science and Technology, 39-1 Hawolgok-dong, Seongbuk-gu, Seoul 136 791 (Korea), Fax: (+82) 2-958-5909 These authors contributed equally to this work.Search for more papers by this authorJaeyoung Lee Dr., Jaeyoung Lee Dr. Department of Radiology, Seoul National University Hospital, 101 Daehangno, Jongno-gu, Seoul 110-744 (Korea)Search for more papers by this authorMoon Hee Han Dr., Moon Hee Han Dr. Department of Radiology, Seoul National University Hospital, 101 Daehangno, Jongno-gu, Seoul 110-744 (Korea)Search for more papers by this authorHyung Jun Ahn Dr., Hyung Jun Ahn Dr. Biomedical Research Center, Korea Institute of Science and Technology, 39-1 Hawolgok-dong, Seongbuk-gu, Seoul 136 791 (Korea), Fax: (+82) 2-958-5909Search for more papers by this authorIn-Chan Yoon Dr., In-Chan Yoon Dr. Biomedical Research Center, Korea Institute of Science and Technology, 39-1 Hawolgok-dong, Seongbuk-gu, Seoul 136 791 (Korea), Fax: (+82) 2-958-5909Search for more papers by this authorKuiwon Choi Dr., Kuiwon Choi Dr. Biomedical Research Center, Korea Institute of Science and Technology, 39-1 Hawolgok-dong, Seongbuk-gu, Seoul 136 791 (Korea), Fax: (+82) 2-958-5909Search for more papers by this authorKwangmeyoung Kim Dr., Kwangmeyoung Kim Dr. Biomedical Research Center, Korea Institute of Science and Technology, 39-1 Hawolgok-dong, Seongbuk-gu, Seoul 136 791 (Korea), Fax: (+82) 2-958-5909Search for more papers by this authorKinam Park Dr., Kinam Park Dr. Department of Biomedical Engineering and Pharmaceutics, Purdue University, West Lafayette, IN 47906 (USA)Search for more papers by this authorIck Chan Kwon Dr., Ick Chan Kwon Dr. ikwon@kist.re.kr Biomedical Research Center, Korea Institute of Science and Technology, 39-1 Hawolgok-dong, Seongbuk-gu, Seoul 136 791 (Korea), Fax: (+82) 2-958-5909Search for more papers by this author Eunah Kang Dr., Eunah Kang Dr. Biomedical Research Center, Korea Institute of Science and Technology, 39-1 Hawolgok-dong, Seongbuk-gu, Seoul 136 791 (Korea), Fax: (+82) 2-958-5909 These authors contributed equally to this work.Search for more papers by this authorHyun Su Min, Hyun Su Min Biomedical Research Center, Korea Institute of Science and Technology, 39-1 Hawolgok-dong, Seongbuk-gu, Seoul 136 791 (Korea), Fax: (+82) 2-958-5909 These authors contributed equally to this work.Search for more papers by this authorJaeyoung Lee Dr., Jaeyoung Lee Dr. Department of Radiology, Seoul National University Hospital, 101 Daehangno, Jongno-gu, Seoul 110-744 (Korea)Search for more papers by this authorMoon Hee Han Dr., Moon Hee Han Dr. Department of Radiology, Seoul National University Hospital, 101 Daehangno, Jongno-gu, Seoul 110-744 (Korea)Search for more papers by this authorHyung Jun Ahn Dr., Hyung Jun Ahn Dr. Biomedical Research Center, Korea Institute of Science and Technology, 39-1 Hawolgok-dong, Seongbuk-gu, Seoul 136 791 (Korea), Fax: (+82) 2-958-5909Search for more papers by this authorIn-Chan Yoon Dr., In-Chan Yoon Dr. Biomedical Research Center, Korea Institute of Science and Technology, 39-1 Hawolgok-dong, Seongbuk-gu, Seoul 136 791 (Korea), Fax: (+82) 2-958-5909Search for more papers by this authorKuiwon Choi Dr., Kuiwon Choi Dr. Biomedical Research Center, Korea Institute of Science and Technology, 39-1 Hawolgok-dong, Seongbuk-gu, Seoul 136 791 (Korea), Fax: (+82) 2-958-5909Search for more papers by this authorKwangmeyoung Kim Dr., Kwangmeyoung Kim Dr. Biomedical Research Center, Korea Institute of Science and Technology, 39-1 Hawolgok-dong, Seongbuk-gu, Seoul 136 791 (Korea), Fax: (+82) 2-958-5909Search for more papers by this authorKinam Park Dr., Kinam Park Dr. Department of Biomedical Engineering and Pharmaceutics, Purdue University, West Lafayette, IN 47906 (USA)Search for more papers by this authorIck Chan Kwon Dr., Ick Chan Kwon Dr. ikwon@kist.re.kr Biomedical Research Center, Korea Institute of Science and Technology, 39-1 Hawolgok-dong, Seongbuk-gu, Seoul 136 791 (Korea), Fax: (+82) 2-958-5909Search for more papers by this author First published: 07 January 2010 https://doi.org/10.1002/anie.200903841Citations: 81 † This work was financially supported by the Real-Time Molecular Imaging Project, 2009K001594, the GRL Program of MEST, and by grants from the Intramural Research Program of KIST (Theragnosis) and the Ministry of Health Welfare and Family Affairs (A062254). Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract A bubbly personality: Coalescence and fusion of carbon dioxide nanobubbles in a tumor leads to microbubbles that can be imaged by ultrasound (see picture). The bubbles are released from gas-generating polymeric nanoparticles that are coated with hydrophobically modified chitosan. Hydrolysis of the polymer poly(BL-PO), which consists of a biodegradable main backbone and a carbonate side chain, results in the release of carbon dioxide. Citing Literature Supporting Information Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Filename Description anie_200903841_sm_miscellaneous_information.pdf332.3 KB miscellaneous_information Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume49, Issue3January 12, 2010Pages 524-528 RelatedInformation
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