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New gold(I) and silver(I) complexes of sulfamethoxazole: Synthesis, X-ray structural characterization and microbiological activities of triphenylphosphine(sulfamethoxazolato-N2)gold(I) and (sulfamethoxazolato)silver(I)

2007; Elsevier BV; Volume: 10; Issue: 9 Linguagem: Inglês

10.1016/j.inoche.2007.06.005

1879-0259

L.L. Marques, Gelson Manzoni de Oliveira, Ernesto Schulz Lang, Marli Matiko Anraku de Campos, Lara Regina Soccol Gris,

Pneumocystis jirovecii pneumonia detection and treatment

Sulfamethoxazole (SMTZ) reacts with Ph3PAuCl and AgCl in methanol/triethylamine to give [Ph3PAu(SMTZ-1H+)] (SMTZ-1H+ = sulfamethoxazolato anion) (1) and [Ag(SMTZ-1H+)] (2). While the lattice of 1 contains single molecules with linear N–Au–P bonds, compound 2 comprises a two-dimensional polymeric assembly of the deprotonated SMTZ ligand and silver ions, which are coordinated by one oxygen and three nitrogens in a distorted tetrahedral array. The microbiologic activities (Mueller–Hinton broth dilution tests) of 1 and 2 were determined in relation to free sulfamethoxazole.