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Living unrelated donor kidney transplantation: A fourteen-year experience

2010; Military Health Department, Ministry of Defance, Serbia; Volume: 67; Issue: 12 Linguagem: Inglês

10.2298/vsp1012998i

2406-0720

Ljiljana Ignjatović, Dragan Jovanović, Goran Kronja, A Dujić, Mihailo Marić, Dragan Ignjatovic, R Hrvacević, Zoran Kovačević, M Petrović, D Elaković, T Marenović, Z Lukić, Miroljub Trkuljić, Bratislav Stanković, Djoko Maksić, J Butorajac, Miodrag Čolić, Biljana Drašković-Pavlović, Nada Kapulica-Kuljic, Nada Draskovic, Sidor Mišović, Borislav Stijelja, Novak Milović, Perica Tosevski, Nikola Filipović, Predrag Romić, Miodrag Jevtić, Miroljub Draskovic, Neven Vavić, Zoran Paunic, Milorad Radojević, Zoran Bjelanovic, Aleksandar Tomić, Predrag Aleksić, Branko Kosevic, D. Mocović, Vladimir Bančević, Zvonko Magić, Danilo Vojvodić, Bela Balint, Gordana Ostojic, Ljiljana Tukic, Jadranka Murgic, Svetozar Pervulov, Sinisa Rusovic, Goran Sjenicic, Vesna Bucan, Merica Milavic-Vujkovic, Dušan Jandrić, Ranko Raicevic, Mirjana Mijušković, Katarina Obrenčević, Dejan Pilcevic, Zoran Cukic, Marijana Petrovic, Milica Petrović, Jelena Tadic, Brankica Terzić, Zeljko Karan, Dubravko Bokonjić, Silva Dobric, Mirjana Antunović, Radmila Bokun, Jovan Dimitrijevic, Biserka Vukomanović-Djurdjević,

Organ Transplantation Techniques and Outcomes

In countries without a national organization for retrieval and distribution of organs of the deceased donors, problem of organ shortage is still not resolved. In order to increase the number of kidney transplantations we started with the program of living unrelated - spousal donors. The aim of this study was to compare treatment outcome and renal graft function in patients receiving the graft from spousal and those receiving ghe graft from living related donors.We retrospectively identified 14 patients who received renal allograft from spousal donors between 1996 and 2009 (group I). The control group consisted of 14 patients who got graft from related donor retrieved from the database and matched than with respect to sex, age, kidney disease, immunological and viral pretransplant status, the initial method of the end stage renal disease treatment and ABO compatibility. In the follow-up period of 41 +/- 38 months we recorded immunosuppressive therapy, surgical complications, episodes of acute rejection, CMV infection and graft function, assessed by serum creatinine levels at the beginning and in the end of the follow-up period. All patients had pretransplant negative cross-match. In ABO incompatible patients pretransplant isoagglutinine titer was zero.The patients with a spousal donor had worse HLA matching. There were no significant differences between the groups in surgical, infective, immunological complications and graft function. Two patients from the group I returned to hemodialysis after 82 and 22 months due to serious comorbidities.In spite of the worse HLA matching, graft survival and function of renal grafts from spousal donors were as good as those retrieved from related donors.