Effects of oophorectomy on biochemical and bone variables in the rat
1992; Elsevier BV; Volume: 18; Issue: 2 Linguagem: Inglês
10.1016/0169-6009(92)90853-6
ISSN1878-0628
AutoresH.A. Morris, Susan Porter, T. C. Durbridge, Robert J. Moore, A. G. Need, B. E. C. Nordin,
Tópico(s)Growth Hormone and Insulin-like Growth Factors
ResumoThe metabolic effects of oophorectomy (Oophx) were studied in 6-month-old rats maintained on a normal chow diet. Nine weeks following operation, Oophx animals had a significantly lower femoral trabecular bone volume (BV/TV) than sham-operated animals; mean (SD) Oophx 8.5 (3.8)%; Sham 13.4 (2.5)%; P = 0.013). They also had a higher urine hydroxyproline (P < 0.001), serum alkaline phosphatase activity (P < 0.001), serum phosphate (P < 0.001) and lower serum albumin (P < 0.001) than the controls. Serum osteocalcin was inversely related to the BV/TV in the Oophx animals at 9 weeks post operation (r = −0.85, P = 0.007, n = 8). A fall in serum ionized calcium from 3 to 9 weeks post operation correlated with a fall in urinary hydroxyproline in the Oophx animals (r = 0.57, P = 0.002, n = 27). The data are consistent with a model of ovarian hormones acting directly to modulate bone cell activity as well as exerting an effect on the renal handling of phosphate.
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