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Sex Differences in Plasma Half-Life of Dextrorphan in Rats Administered Dextromethorphan

1978; Elsevier BV; Volume: 67; Issue: 9 Linguagem: Inglês

10.1002/jps.2600670939

1520-6017

Ramachander Gollamudi, K.R. Bapatla, Jane Frances Emele,

Biochemical Analysis and Sensing Techniques

Male and female rats exhibited striking differences in their ability to metabolize dextromethorphan. Upon oral administration of this drug, the plasma half-life of dextrorphan, a major biotransformation product formed by O-demethylation, was 40 min in the female rat and min in the male.