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Potentiation of a monoamine oxidase inhibitor by tryptophan

1969; Elsevier BV; Volume: 7; Issue: 2 Linguagem: Inglês

10.1016/0022-3956(69)90013-2

1879-1379

Alexander H. Glassman, Stanley R. Platman,

Genetic Neurodegenerative Diseases

This double blind study investigated the reported potentiation of an MAO inhibitor by tryptophan. Twenty seriously depressed patients were placed on phenelzine sulfate. Half of these patients received supplements of tryptophan while the remainder received a placebo. Those receiving the tryptophan supplements showed significantly more improvement as measured by a modified version of the Hamilton scale. The possible pathways for the mediation of this tryptophan effect are discussed.