Electrochemically assisted co-precipitation of protein with calcium phosphate coatings on titanium alloy
2004; Elsevier BV; Volume: 25; Issue: 23 Linguagem: Inglês
10.1016/j.biomaterials.2003.12.045
ISSN1878-5905
AutoresXiaoliang Cheng, Mark Filiaggi, Sharon G. Roscoe,
Tópico(s)Polymer Surface Interaction Studies
ResumoA bovine serum albumin protein-containing calcium phosphate coating (BSA/brushite) was prepared by electrochemically assisted co-precipitation onto a hydroxyapatite (HA) coated Ti-6Al-4 V surface. Electrochemically assisted co-precipitation of BSA/brushite coatings onto HA resulted in a 70-fold increase in BSA inclusion compared to simple adsorption, and was subsequently released by a slower mechanism (15% loss over 70 h). Thus, this electrochemically assisted co-precipitation technique provides an efficient method of protein incorporation at physiological temperature, with a potential for sustained release of therapeutic agents as may be required for metallic implant fixation.
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