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Treatment of Acute Hemorrhagic Pancreatitis with Adrenocorticosteroids

1959; American Medical Association; Volume: 78; Issue: 5 Linguagem: Inglês

10.1001/archsurg.1959.04320050133020

2376-3566

Marion C. Anderson,

Pancreatitis Pathology and Treatment

A limited number of case reports have appeared in the literature which describe a beneficial response following the treatment of acute pancreatitis with adrenocorticosteroids. 4,6,9-13,16,19 The exact mechanism responsible for this improvement is not known; however, prevention of circulatory failure 5-7 and anti-inflammatory, 8,9,13,17 antienzymatic, 16 and antiallergic 13 effects have been suggested. Included in the present study are two case reports of documented acute pancreatitis following abdominal operations. Both patients recovered after institution of abrenocorticosteroid therapy in conjunction with other supportive measures. Report of Cases Case 1. —A 47-year-old white woman was hospitalized on July 28, 1954, with a four-week history of cramping right-side abdominal pain, nausea, vomiting, and frequent eructations. Abnormal physical findings included a blood pressure of 210/110 and a firm, movable mass, 4 cm. in diameter, in the right midabdomen. Routine studies of blood and urine were within normal limits. Colon x-rays revealed a napkin-ring deformity