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Imaging without lenses: achievements and remaining challenges of wide-field on-chip microscopy

2012; Nature Portfolio; Volume: 9; Issue: 9 Linguagem: Inglês

10.1038/nmeth.2114

1548-7105

Alon Greenbaum, Wei Luo, Ting‐Wei Su, Zoltán Göröcs, Liang Xue, Serhan O. Isikman, Ahmet F. Coskun, Onur Mudanyali, Aydogan Özcan,

Image Processing Techniques and Applications

We discuss unique features of lens-free computational imaging tools and report some of their emerging results for wide-field on-chip microscopy, such as the achievement of a numerical aperture (NA) of ∼0.8-0.9 across a field of view (FOV) of more than 20 mm(2) or an NA of ∼0.1 across a FOV of ∼18 cm(2), which corresponds to an image with more than 1.5 gigapixels. We also discuss the current challenges that these computational on-chip microscopes face, shedding light on their future directions and applications.