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Making It Easier to Regulate Protein Stability

2010; Elsevier BV; Volume: 17; Issue: 9 Linguagem: Inglês

10.1016/j.chembiol.2010.09.004

1879-1301

Erin K. Schrader, Shameika R. Wilmington, Andreas Matouschek,

Peptidase Inhibition and Analysis

The ability to induce degradation of a protein of interest is a powerful experimental tool used to ascertain protein function. Iwamoto et al. (2010) describe a method that allows reversible and dose-dependent modulation of the stability of any target protein.