The influence of chemotherapy on plasma coagulation and fibrinolytic systems in lung cancer patients
1989; Wiley; Volume: 63; Issue: 4 Linguagem: Inglês
10.1002/1097-0142(19890215)63
ISSN1097-0142
AutoresMaria Armila Ruiz, Isabel Marugán, A. Estellés, I. Navarro, Francisco España, V. Alberola, Luo Juan, J Aznar, J Garcı́a-Conde,
Tópico(s)Platelet Disorders and Treatments
ResumoAfter the administration of cytostatic drugs, an increase in thromboembolic phenomena has been described in cancer patients. The authors studied the changes in plasmatic coagulation and fibrinolysis in 40 patients with nonoperable Stage III and IV lung cancer after cytostatic chemotherapy. The results show significant postchemotherapy increases in fibrinopeptide A levels, as well as a decrease in fibrinolytic activity reflected by a drop in functional tissue activator. Also the authors studied the potential accumulative effect of three chemotherapy cycles. A significant increase in functional plasminogen activator inhibitor has been noted. Chemotherapy is apparently capable of conditioning a decrease in fibrinolytic activity in these cancer patients that could be related to the enhanced tendency to developing thromboembolic phenomena after cytostatic chemotherapy.
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